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Training4CRM

Cell-based Regenerative Medicine for neurodegenerative diseases

Nothing in life is to be feared, it is only to be understood.
Now is the time to understand more, so that we may fear less.

Marie Curie

Training4CRM addresses gaps in Cell-based Regenerative Medicine (CRM) for treatment of neurodegenerative disorders (e.g. Parkinson’s (PD), Huntington’s (HD) and Epilepsy (EPI)), which occur as a result of progressive loss of structure, function and/or death of neurons in the brain. These disorders have a high prevalence and are associated with short- and long-term impairments and disabilities with high emotional, financial and social burden to the patients, their families and friends.

A Marie Skłodowska-Curie Initial Training Network. Funded by the European Union Horizon 2020 Programme
  • ESR1

    ESR1

    To design, fabricate and characterise polymer and carbon based optoelectrical waveguides as future potential cell carrying implants with both optical and electrical properties.

    Shashank Vasudevan
    Technical University of Denmark
  • ESR2

    ESR2

    To fabricate perfusable 3D hybrid scaffolds using novel hybrid 3D printing technology that simultaneously enables filament extrusion printing and hydrogel/bio-printing, incorporating in the same scaffold different material properties.

    Hakan Gürbüz
    Felix 3D Printers
  • ESR3

    ESR3

    To fabricate various surface nanotopographies and microarchitectures in different materials, investigating their role in how cells make different developmental decisions.

    Afia Asif
    Technical University of Denmark
  • ESR4

    ESR4

    Electronic circuits for optical stimulation, bioimpedance and  electrochemical sensing.

    Alireza Mesri
    Analog Circuits Designer
    Politecnico di Milano
  • ESR5

    ESR5

    To design, fabricate and characterise perfusion based bioreactor and sensor array systems for optimising and screening of 3D cell culture conditions and modelling neuronal disorders.

    Mohammad Salman Kahn
    Technical University of Denmark
  • ESR6

    ESR6

    Perform linear and non-linear (memristive) properties of cells and tissues. To study the behaviour of the methods developed in some of the other ESRs in animal models.

    Christin Schuelke
    University of Oslo
  • ESR7

    ESR7

    To fabricate, characterise, apply 3D IPN scaffolds loaded with different ThFs as factor delivery systems (FDS) for improved hSC stability and induced differentiation.

    Mozhdeh Ghani
    Biomodics
  • ESR8

    ESR8

    Develop, characterise hSCs-producing ThFs, and autocrine/paracrine effects.

    Cristina Salado
    Universitat de Barcelona
  • ESR9

    ESR9

    Develop human neurons releasing neurotransmitters of interest, either on the basis of a highly enriched population of one neuron subtype or by selectively stimulating the release from the desired population of neurons in vitro and/or in vivo.

    Ana Ramos
    University of Lund
  • ESR10

    ESR10

    To create a 3D microenvironment that allows scaling up of existing mini-brains towards “small brains”.

    Theresa Rothenbücher
    Universidad Autonoma de Madrid
  • ESR11

    ESR11

    To create individualized blood vessels and brain networks in perfusable 3D scaffolds using de- and recellularization technology.

    Robin Simsa
    Verigraft
  • ESR12

    ESR12

    To study therapeutic factor releasing cell carrier implants in clinically relevant animal disease models.

    Camille Baumlin
    Universidad Autonoma de Madrid
  • ESR13

    ESR13

    To provide neurotransmitter releasing cell carrier implants in clinically relevant animal disease models (PD and HD).

    Universidad Autonoma de Madrid
  • ESR14

    ESR14

    Study the applicability of the GABA releasing cells with or without carrier implants in clinically relevant animal models of Epilepsy.

    Eliška Waloschková
    Lund University
  • ESR15

    ESR15

    To design, fabricate and characterise a miniaturised instrument for monitoring both linear and non-linear (memristive) properties of cells and tissues, interfaced with the electrochemical sensor developed by ESR4.

    André Cunha
    Embedded Systems and Software Engineer & Physicist
    University of Oslo
Work Package: Micro- and Nanofabrication

Work Package: Micro- and Nanofabrication

Training ESRs in the use of a range of different fast prototyping- and cleanroom based micro- and nanofabrication techniques to become knowledgeable and skilled in how to engineer:

  • 3D structures in different materials and architectures for use as CCS, FDS, OEWs, sensors and/or actuators
  • Perfusion based 3D LOC systems with integrated bioreactors and sensors arrays systems
  • Electronic components for wireless control and communication

Contact: Jenny Emnéus at jenny.emneus@nanotech,dtu.dk

Work Package: Biotechnology

Work Package: Biotechnology

Training ESRs in hSC (hiPSCs, hNSCs) production- and differentiation, cell and molecular biology-, and tissue engineering techniques to become knowledgeable and skilled in how to:

  • Produce and differentiate hSCs into specific neural phenotypes under good manufacturing practices (GMP)
  • Genetically modify hSCs to stabilize and control developmental stem cell fate choices in vitro
  • Create in-vivo-like artificial tissues and organs.

Contact Alberto Martinéz Serrano at amserrano@cbm.csic.es

Work Package: Preclinical studies

Work Package: Preclinical studies

Training ESRs in pre-clinical- and in vivo monitoring studies to become knowledgeable and skilled in how to:

  • Deliver therapeutic factors (incl. neurotrophins, neuropeptides), and neurotransmitters in the healthy and diseased brain
  • Monitor the therapeutic efficacy of cell based interventions in suitable models of nervous system disease, e.g. PD, HD, Epilepsy
  • Design and conduct pre-clinical research as a means to prepare for future clinical trials

Contact Merab Kokaia at merab.kokaia@med.lu.se

Work Package: Education and Training

Work Package: Education and Training

  • To train a new generation of truly interdisciplinary researchers in cell-based regenerative medicine, possessing scientific and transferable skills highly attractive to both the industrial and academic sectors, and capable of being future focal points in CRM
  • To establish a multi-sectorial training and research network that reaches into the future, where academia and industry share and break new knowledge
  • To implement and monitor the Training4CRM training activities.

Contact Ørjan G. Martinsen at o.g.martinsen@fys.uio.no

Work Package: Communication & Exploitation

Work Package: Communication & Exploitation

  • To create a comprehensive communication plan that ensures target-oriented and meaningful dissemination of Training4CRM results to different stakeholders, incl. scientific community, industry, policy makers, end-users and the general public
  • To create an exploitation strategy that secures network wide attention to innovation, IPR and exploitation of both expected and unforeseen Training4CRM results
  • To implement and follow up on the communication and exploitation strategies

Contact Josep Maria Canals Coll at jmcanals@ub.edu

  • Research School 1: Micro and Nanoengineering in Milano/Venice (6/11/2017 - 11/11/2017)

    Research School 1: Micro and Nanoengineering in Milano/Venice (6/11/2017 - 11/11/2017)

    Cross-disciplinary training of fellows in a range of different fast prototyping- and cleanroom based micro- and nanofabrication techniques to become knowledgeable and skilled in how to fabricate 3D structures in different materials, miniaturised 3D lab-on-a-chip systems and electronic components for wireless control and communication with the developed sensors and actuators, including system design and modelling. Transferable skills: Public engagement and responsible research and innovation.
  • Research School 2: Biotechnology in Madrid (29/4/2018 - 5/5/2018)

    Research School 2: Biotechnology in Madrid (29/4/2018 - 5/5/2018)

    Cross-disciplinary training of fellows in regenerative medicine, cell and gene therapy concepts, stem cell biology, and molecular and cellular biology methods to identify and characterise cellular phenotypes. Transferable skills: Sex and gender in science and continued public engagement.
  • Research School 3: Pre-clinical Studies and In Vivo Monitoring in Lund (25/9/2018 - 29/9/2018)

    Research School 3: Pre-clinical Studies and In Vivo Monitoring in Lund (25/9/2018 - 29/9/2018)

    Cross-disciplinary training of fellows in pre-clinical- and in vivo monitoring studies to become knowledgeable and skilled in how to deliver therapeutic factors and neurotransmitters in the healthy and diseased brain, monitor the therapeutic efficacy of cell based interventions in suitable models of nervous system disease, and design and conduct pre-clinical research as a means to prepare for future clinical trials. Transferable skills: Research management and research history.
  • Research school 4: Exploitation of Knowledge in Barcelona (TBA)

    Research school 4: Exploitation of Knowledge in Barcelona (TBA)

    Training of fellows in innovation management, IPR and exploitation of scientific knowledge and giving the fellows insights to the process of transforming scientific results into commercially viable solutions, incl. pitfalls and possibilities. The fellows will make posters on their innovation and business plan to be presented at our Training4CRM network conference (public event) scheduled for the end of the project.

 

Professor Jenny Emnéus

Project leader

Email: jenny.emneus@nanotech.dtu.dk
Phone: +45 4525 6867
Mobile: +45 2547 3548

 

Mette Christiansen

Project Support

Email: mech@nanotech.dtu.dk
Phone: +45 4525 5795
Mobile: +45 5244 1955

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